PROTOCATECHUALDEHYDE RESCUES OXYGEN-GLUCOSE DEPRIVATION/REOXYGENATION-INDUCED ENDOTHELIAL CELLS INJURY BY INDUCING AUTOPHAGY AND INHIBITING APOPTOSIS VIA REGULATION OF SIRT1

Background: Oxidative stress-induced endothelial cell death, such as apoptosis and autophagy, plays a critical role in ischemia-reperfusion injury.Protocatechualdehyde (PCA) is a major bioactive component of the traditional Chinese medicine Salvia miltiorrhiza Bunge (Lamiaceae), and it has been proved to be effective in the prevention and treatment

In this paper we study Controlled Query Evaluation (CQE), a declarative approach to privacy-preserving query answering over databases, knowledge bases, and ontologies.CQE is based on the notion of censor, which defines the answers to each query posed to the data/knowledge base.We investigate both semantic and computational properties of CQE in the

ABSTRACT The prompt rollout of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine is facilitating population immunity, which is becoming more dominant than natural infection-mediated immunity.In the midst of coronavirus disease 2019 (COVID-19) vaccine deployment, understanding the epitope profiles of vaccine-elicited anti

To contribute to healthcare improvements, qualitative health research must adapt to the demanding pace of constantly changing healthcare practices and policies.To meet this challenge, researchers need methods for rigorous and rapid data analysis.This article introduces the Rapid Group Analysis Process (Rap-GAP), Face Palette a new approach for rapi

Snakebites can present local or systemic envenomation, while neurotoxicity and respiratory paralysis are the main cause of death.The mainstay of management is anti-snake venom (ASV), which is highly effective, but Toys liable to cause severe adverse reactions including anaphylaxis.The types of adverse reaction to polyvalent anti-snake venom have no